CTLA4, T cell function, and long term immunity: an interview with Dr. Mark K. Slifka. Interview by Helene F. Rosenberg.
نویسنده
چکیده
Cytotoxic T lymphocyte antigen-4 (CTLA-4/CD152) is a member of the CD28 family of T cell effector antigens. Current belief, based primarily on results from gene-deleted mice, is that CTLA-4 promotes suppression of T cell proliferation. In this manuscript, Mark Slifka and colleagues compare antiviral responses of unmanipulated virus-specific CTLA-4 and CTLA-4 T cells. The results of this work suggest that the CTLA-4 antigen has no specific role in suppressing T cell proliferation in response to viral stimulation.
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ورودعنوان ژورنال:
- Journal of leukocyte biology
دوره 81 5 شماره
صفحات -
تاریخ انتشار 2007